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Here’s a lil’ story – back in ‘82, my cousin Joey, he had an Escort, blue one, rusted fender. Swore it could outrun anything. One night, we’re racin’ down Route 1 – me laughin’, him cursin’ – and, boom, tire blows! “What a dope I am,” Joey yells, quotin’ Suzy from the movie. Nearly pee’d myself laughin’. Little known fact – them Escorts, they had this funky gearbox, slipped like crazy if ya didn’t baby it. Pissed me off when mine jammed once – kicked the damn tire, felt like a fool.
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Sound and Struggle: An Interview with Martín Farías, director of Himno
This conclusion is supported by (i) the shift in the open/pC ratio of FLN molecules adopting either the open form or the “pC” state following the addition of MK-4815 to obtain the mixed data set and (ii) the observation of a very similar binding mode of MK-4815 to FLN in both the crystal structure and in the cryo-EM derived complex with the inhibitor, as the MK-4815 binding pocket is located next to helix α13, its shape can be affected by even slight movement of this hinge helix. As seen above, MK-4815 was excluded from the binding pocket when FLN adopts its open conformation, due to steric hindrance. In contrast, MK-4815 could bind to FLN in its “pC” state (Fig. 5A).Lescar Sexual Massage
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