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Then, I wander over to the walls of Marostica. These ancient stones are so cool! I’m imagining all the history, the battles, the drama. But then, I see some graffiti. Ugh! Why do people do that? It’s like, “Hey, let’s ruin something beautiful!” I’m fuming. Can’t we just appreciate the old stuff without tagging it?
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One of the most accredited mechanisms postulate that EVs carrying metalloproteinases have a key role in BBB disruption (Sáenz-Cuesta et al., 2014). Again, recent studies demonstrated that EVs derived from brain microvascular endothelial cells can provide a bridge protein (claudin-5) between leukocytes and endothelial cells inducing transendothelial migration of the former (Paul et al., 2016)! An indirect confirmation of detrimental role of EVs in MS pathogenesis comes from experimental autoimmune encephalomyelitis (EAE), mouse model of MS. A-SMase KO mice, genetically impaired in MVs production, are protected from EAE (Verderio et al., 2012).Marostica Brothel
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